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FLASH GENE

Symbol

EMSY

contributors: mct - updated : 02-12-2021

HGNC name	EMSY transcriptional repressor, BRCA2 interacting
HGNC id	18071

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001300942 22 - 7049 NP_001287871 - 1337 - 2019 31154666 NM_001300944 21 - 7007 NP_001287873 - 1323 - 2019 31154666 NM_001300943 21 - 7007 NP_001287872 - 1323 - 2019 31154666 NM_020193 21 - 7004 NP_064578 - 1323 - 2019 31154666

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus cervix   highly   female system placenta     highly   male system prostate       Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	EMSY N terminal domain (ENT)
	a TUDOR-like domain (AGENET domain)

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	repressor protein having the capacity to bind a small epitope within the BRCA2 exon 3-encoded transcriptional activation domain and specially silencing this activity
	playing a role at least partially in the regulation of chromatin
	involved in DNA damage repair, genomic instability, and chromatin remoldin
	EMSY played an oncogenic role in the progression of ovarian cancer cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	with BRCA2 (links the BRCA2 pathway to sporadic breast and ovarian cancer)
	bind BRCA2 and inactivate the function of BRCA2, leading to the development of sporadic breast and ovarian cancers
	ZNF131, recruits EMSY to a large number of active, H3K4me3 marked promoters

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in sporadic breast cancer and higher-grade ovarian cancer with poor prognosis tumoral     --over   in various sporadic cancers

Susceptibility

to prostate cancer and prostate cancer death

Variant & Polymorphism SNP

the most significant association with prostate cancer and death is at rs12277366

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary might be a promising target for the treatment of ovarian cancer

ANIMAL & CELL MODELS