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FLASH GENE
Symbol HUS1B contributors: mct/npt - updated : 28-01-2009
HGNC name HUS1 checkpoint homolog b (S. pombe)
HGNC id 16485
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1026 31 278 - Mungall (2003)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to HUS1
Homologene
FAMILY
  • HUS1 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • playing a role in regulating cell cycle checkpoints and genomic integrity
  • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • HUS1B-RAD1-RAD9A in a PCNA-like structure
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RAD9A and RAD9B (these proteins can combinatorially assemble into distinct 9-1-1 clamps that may have distinct biological functions) (Dufault 2003)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    induce cell death
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS