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FLASH GENE
Symbol ATP6V0D1 contributors: npt/ - updated : 20-09-2004
HGNC name ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
HGNC id 13724
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1688 - 351 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • the N terminus is blocked
  • HOMOLOGY
    interspecies homolog to C.elegans Y38f2al.e
    ortholog to murine physophilin
    Homologene
    FAMILY
  • V-ATPase V0D/AC39 subunit family
  • CATEGORY enzyme , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • regulating ATP binding and hydrolysis by the A and B subunits
  • in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles (Pietrement 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    text proton transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of vacuolar ATPase (V-ATPase) proton pump
  • complex with ATP6C, ATP6E binding to the hexamer ATP6A/ATP6B
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS