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FLASH GENE
Symbol FKBP11 contributors: mct - updated : 17-03-2012
HGNC name FK506 binding protein 11, 19 kDa
HGNC id 18624
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 767 - 201 - 2006 16596453
5 - 561 - 99 - 2006 16596453
6 - 986 - 146 - 2006 16596453
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrinepancreas   highly
Hearing/Equilibriumear   highly
Reproductivefemale systembreastmammary gland highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cleavable N-terminal signal sequence followed by a putative peptidyl-prolyl cis/trans isomerase domain with homology to FKBP12
  • three tetratricopeptide repeat (TPR) motifs consistent with nuclear transcript or chaperone activity
  • HOMOLOGY
    Homologene
    FAMILY
  • immunophilin class of proteins family
  • FK506-binding protein (FKBP) family of peptidyl-prolyl cis/trans isomerases
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • binding protein FKBP11 for the immunosuppressive agents FK506-rapamycin
  • intrinsic peptidyl-prolyl cis-trans isomerase activity
  • only protein it was found to interact with IFITM5 in osteoblasts, while IFITM5 interacts with several proteins in fibroblasts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • IFITM5 forms a complex with FKBP11-CD81-PTGFRN
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction IFITM5-FKBP11 in osteoblasts, and FKBP11 was associated with CD81, which interacts with prostaglandin F2 receptor negative regulator (PTGFRN) and CD9
  • associates with CD81, which interacts with PTGFRN and CD9, resulting in the formation of a FKBP11–CD81–[PTGFRN/CD9] complex in osteoblast
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS