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FLASH GENE
Symbol PLSCR4 contributors: mct - updated : 10-12-2010
HGNC name phospholipid scramblase 4
HGNC id 16497
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3014 - 224 - -
7 - 3042 36.9 239 - 2000 10930526
9 - 3312 36.9 329 - 2000 10930526
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Cardiovascularheart    
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
 liver    
Endocrinepancreas    
Nervousbrain    
Reproductivefemale systemuterus    Homo sapiens
 male systemtestis   
 male systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple PXXP motifs
  • a PPXY motif located near the N terminus implying the potential for interaction with SH3 or WW domain-containing proteins
  • a Ca2+ binding motif that is a novel type of Ca2+ binding motif
  • conjugated LipoP , Other
    HOMOLOGY
    Homologene
    FAMILY
  • phospholipid scramblase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • mediating calcium dependent bidirectional movement between membrane bilayers in adjured, activated, or apoptotic cells
  • may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in recognition of apoptotic and injured cells by the reticuloendothelial system
  • facilitate the translocation of aminophospholipids from the inner to the exterior leaf of the cell membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • with PLSCR1, interact directly with the CD4 receptor at the cell surface of T lymphocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS