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FLASH GENE
Symbol GMEB1 contributors: mct - updated : 08-02-2011
HGNC name glucocorticoid modulatory element binding protein 1
HGNC id 4370
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1960 64 573 - 2000 10734202
including exon 2
10 splicing 1944 63 563 - 2000 10734202
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine   
Nervousganglia    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a region containing the sequence KDWK necessary for DNA binding
  • a SAND (DNA binding) domain
  • mono polymer homomer , heteromer , dimer , oligo
    HOMOLOGY
    interspecies homolog to rattus glucocorticoid modulatory element binding protein
    Homologene
    FAMILY
  • KDWK family of proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • modulator of transactivation by the glucocorticoid receptor
  • essential for parvovirus DNA replication
  • attenuated the Fas-mediated activation of these caspases and the subsequent apoptosis
  • is potentially an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis
  • functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress
  • can blocks pro-apoptosis signals induced by a variety of stresses
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with GMEB2
  • INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • binding glucocorticoid receptor modulatory elements
  • interacts with the prodomain of procaspase-2, thereby disrupting its autoactivation and the induction of apoptosis
  • interaction with procaspase-2, -8, or -9 prevents caspase oligomerization and maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS