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FLASH GENE
Symbol CYP39A1 contributors: npt - updated : 09-07-2002
HGNC name cytochrome P450, family 39, subfamily A, polypeptide 1
HGNC id 17449
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2288 54 469 - Nelson (2004)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Nervousnerve   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
interspecies ortholog to murine Cyp39a1
Homologene
FAMILY
  • cytochrome P450 family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • hydroxylating, preferentialy, 24-hydroxycholesterol
  • catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids
  • endoplasmic reticulum protein which is involved in the conversion of cholesterol to bile acids
  • preferentially catalyzes the 7alpha-hydroxylation of 24-hydroxycholesterol and may play a role in the alternative bile acid synthesis pathway in the liver
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • heme
  • protein flavoprotein P450 oxidoreductase POR
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS