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FLASH GENE
Symbol OLIG1 contributors: mct/shn - updated : 17-01-2024
HGNC name oligodendrocyte transcription factor 1
HGNC id 16983
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2293 - 271 - 2000 10719889
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiensAdult
 brain     Homo sapiensFetal
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoligodendrocyte
cell lineage expressed exclusively in oligodendrocytes and oligodendrocyte progenitors
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH) domain
  • HOMOLOGY
    interspecies ortholog to Olig1, Mus musculus
    ortholog to Olig1, Rattus norvegicus
    ortholog to olig1, Danio rerio
    ortholog to OLIG1, Pan troglodytes
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text specifically expressed in zones of neuroepithelium in the oligodendrocyte precursors
    basic FUNCTION
  • promoting formation of a chondroitin sulfate proteoglycan-positive glial progenitor
  • has roles in development and maturation of oligodendrocytes
  • requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis
  • controlling the development of neural crest cells, astrocytes and oligodendrocytes, three neuroectodermal-derived cells
  • important for differentiation of oligodendrocyte precursors into myelin-forming oligodendrocytes during development and is thought to play a crucial role in remyelination during multiple sclerosis (Li 2007)
  • transcription factor that is essential for oligodendrogenesis, but is not actively required in differentiated oligodendrocytes (Gong 2008)
  • promotes oligodendrocyte maturation and is required for myelin repair (Chen 2009)
  • play a role in ventral telencephalic neurogenesis
  • unique role for OLIG1 in promoting oligodendrocyte progenitor cell commitment, differentiation, and subsequent myelination primarily in brain, but not spinal cord
  • OLIG1 may play an important role in the specification of the prosensory domain in the developing inner ear
  • has a critical function in regulation of postnatal neural progenitor cell production in response to NOG
  • functional roles of OLIG1 and OLIG2 in directing neuronal and glial formation during different stages in development
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of GPR17
  • associates physically with another myelin-associated transcription factor, SOX10, and the OLIG1/SOX10 complex activates MBP(myelin basic protein) transcription via conserved DNA sequence motifs in theMBP promoter region
  • stage-specific regulatory role for OLIG2, mediated by OLIG1 that conveys opposing functions on the differentiation and maturation of oligodendrocytes
  • OLIG1 is an essential repressor of DLX1/DLX2 and interneuron production in developing mammalian brain
  • overexpression of HTATIP2 was found to sequester the transcription factor OLIG1 in the cytoplasm and weaken its nuclear translocation due to the interaction between HTATIP2 and OLIG1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oligodendroglial tumors and anaplastic astrocytomas
    constitutional   amplification    
    Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome
    constitutional   deletion    
    in the cerebellum, deletion of both OLIG2 and OLIG1 results in impaired genesis of Purkinje cells (PCs) and Pax2(+) interneurons
    Susceptibility susceptibility to multiple sclerosis
    Variant & Polymorphism
    Candidate gene OLIG1 protein expression could be utilized as a novel prognostic factor, which could aid in deciding which non-small cell lung cancer patients might benefit from more aggressive therapy
    Marker
  • a molecular marker for human glial brain tumors
  • Therapy target
    ANIMAL & CELL MODELS
  • in Olig1(-/-)2(-/-) double-mutant mice motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished
  • Olig1 is triplicated and overexpressed in the Ts65Dn mouse forebrain (mouse models of Down syndrome) displaying cognitive deficits
  • Olig1-null neonatal mice showed significant hypomyelination after moderate neonatal stroke