basic FUNCTION
| promoting formation of a chondroitin sulfate proteoglycan-positive glial progenitor |
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has roles in development and maturation of oligodendrocytes |
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requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis |
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controlling the development of neural crest cells, astrocytes and oligodendrocytes, three neuroectodermal-derived cells |
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important for differentiation of oligodendrocyte precursors into myelin-forming oligodendrocytes during development and is thought to play a crucial role in remyelination during multiple sclerosis (Li 2007) |
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transcription factor that is essential for oligodendrogenesis, but is not actively required in differentiated oligodendrocytes (Gong 2008) |
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promotes oligodendrocyte maturation and is required for myelin repair (Chen 2009) |
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play a role in ventral telencephalic neurogenesis |
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unique role for OLIG1 in promoting oligodendrocyte progenitor cell commitment, differentiation, and subsequent myelination primarily in brain, but not spinal cord |
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OLIG1 may play an important role in the specification of the prosensory domain in the developing inner ear |
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has a critical function in regulation of postnatal neural progenitor cell production in response to NOG |
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functional roles of OLIG1 and OLIG2 in directing neuronal and glial formation during different stages in development |