Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC4A8 contributors: mct - updated : 08-04-2014
HGNC name solute carrier family 4, sodium bicarbonate cotransporter, member 8
HGNC id 11034
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 4010 - 1044 - 2008 1857771
25 - 11794 - 1093 - 2008 1857771
25 - 11740 - 1040 - 2008 1857771
15 - 2278 - 638 - 2008 1857771
15 - 2332 - 691 - 2008 1857771
- - 3131 - 747 - 2008 1857771
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Nervousbrain     Homo sapiens
 brainforebraincerebral cortex   Mus musculus
 brain     Rattus norvegicusAdult
 brainforebraincerebral cortex   Mus musculus
 brainhindbraincerebellum   Mus musculus
 brainlimbic systemhippocampus   Mus musculus
Reproductivemale systemtestis    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Muscularstriatumskeletal   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervouspyramidal cell Mus musculus
Visualcone photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal PDZ-interacting motifs
  • HOMOLOGY
    interspecies homolog to murine Ncbe
    intraspecies homolog to SLC4A5
    Homologene
    FAMILY
  • anion exchanger (TC 2.A.31) family
  • SLC4 family of bicarbonate transporters
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • is in most glutamatergic axon terminals, and is also present in the terminals of parvalbumin-positive GABAergic cells
  • basic FUNCTION
  • playing an essential role in maintaining sensory cells integrity in both visual and auditory systems
  • having inorganic anion exchanger activity
  • is in a position to contribute substantially to pH(i) regulation in multiple CNS neurons
  • potential role in mediating substantial Na+ reabsorption in the cortical collecting duct (CCD)
  • modulates potentially glutamate release in a pH-dependent manner
  • modulate excitatory neurotransmission in hippocampus
  • can regulate glutamatergic transmission throughout the brain, and is a possible regulator of GABAergic neurotransmission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CA2 interacts at high affinity with the C-terminal (Ct) domains of SLC4A8, but can bind to GST-SLC4-Ct fusion proteins only when the CA2 is immobilized and the fusion protein is soluble, and not vice versa
  • cell & other
    REGULATION
    Other its activity is inhibited by PRKACA and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS