basic FUNCTION
| mitotic kinase, involved in the activation of lymphoid cells |
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playing a suggested role in the process of spermatogenesis (support testicular functions) |
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plays a role in the formation of spindle midzone and in cytokinesis |
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with MAPK14 are activated in a cell-cycle-dependent manner in neuronal progenitor cells and inhibition of this pathway disrupts progenitor proliferation and self-renewal, a core feature of progenitors (Dougherty 2005) |
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plays an important role in the progenitors, and further implicates the MAPK14 pathway in general, as an important regulator of progenitor proliferation and self-renewal (Dougherty 2005) |
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enhanced expression of PBK may facilitate tumour growth by mediating MAPK14 activation and by helping cells to overcome DNA damage (Ayllon 2007) |
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having a role in augmenting tumor cell growth following transient appearance in different types of progenitor cells (Nandi 2007) |
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mediates promyelocyte proliferation via NFE2L2-regulated cell cycle progression and apoptosis |