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FLASH GENE
Symbol RBBP7 contributors: mct/npt - updated : 04-02-2009
HGNC name retinoblastoma binding protein 7
HGNC id 9890
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2021 47.7 425 - Murzina (2008)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Reproductivefemale systemuteruscervix highly
 female systemuterus  highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six WD40 repeats
  • HOMOLOGY
    interspecies homolog to murine Rbbp7
    homolog to yeast Mis16
    intraspecies homolog to highly to RBBP4
    Homologene
    FAMILY
  • WD repeat RBAP46/RBAP48/MSI1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • histone chaperones that play key roles in establishing and maintaining chromatin structure (Murzina 2008)
  • required with RBBP4 for the recruitment of CENPA to the kinetochores
  • associated with chromatin remodeling, histone deacetylation, and transcription repression, as proteins associated with the DNA-bound ESR1 (Creekmore 2008)
  • having a role in regulating gene expression (Creekmore 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of PRC2 complex containing four core components: EZH2, EED, SUZ12, and RBBP7
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with ESR1 (modulates estrogen responsiveness in a gene-specific manner) (Creekmore 2008)
  • RBBP4-MTA1 interaction is essential for the integration of RBBP7/RBBP4 into the NuRD complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS