Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GLMN contributors: mct - updated : 08-09-2015
HGNC name glomulin, FKBP associated protein
HGNC id 14373
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2042 68 594 - 2003 12604780
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselcapillary    Mus musculus
 vesselvein    Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothvessel   Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
basic FUNCTION
  • playing a role in differentiation of vascular smooth muscle cells and in vascular morphogenesis especially in cutaneous veins
  • important role for glomulin in blood vessel development and/or maintenance
  • adopts a HEAT-like repeat fold that tightly binds the E2-interacting surface of RBX1, inhibiting CRL-mediated chain formation by the E2 CDC34
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component complex between GLMN, RBX1, and a fragment of CUL1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with FK506-binding proteins (FKBPs) such as FKBP1A, FKBP4
  • GLMN binds directly to the RING domain of RBX1 and inhibits its E3 ubiquitin ligase activity
  • GLMN modulates the E3 activity of CRL1(FBXW7)
  • functional connection between GLMN and RBX1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GVM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS