basic FUNCTION
| involved in transcriptional coactivation by steroid receptors |
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enhances cellular proliferation and differentiation and promotes apoptosis |
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SRA may act to confer functional specificity upon multiprotein complexes recruited by liganded receptors during transcriptional activation |
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may play a role in tumorigenesis |
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play a role in steroidogenesis and adrena biology |
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can function as a RNA |
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coactivates glucortcoid, retinoic acid receptors and the muscle differentiation factor MyoD |
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functions as a thyroid hormone receptor coactivator |
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plays a critical role in nuclear hormone receptor activity |
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plays an important role in the expression of StAR and Mc2R genes |
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SRA is important to stabilize complexes of SF-1 and Dax-1 for the recruitment of p160 coactivators to regulate target gene expression in steroidogenesis |
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PUS1 and PUS3 -dependent pseudouridylation of SRA1 is a highly complex posttranscriptional mechanism that controls a coactivator-corepressor switch in SRA1 with major consequences for NR signaling |
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has the ability to modulate the action of steroid receptors (ESR1, AR and GR) likely through direct interactions |
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as its RNA, has the potential to be involved in many critical pathways and putatively directly participates to the regulation of gene expression |
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play a crucial role in nuclear receptor transcriptional regulation |