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FLASH GENE
Symbol HELZ contributors: mct - updated : 07-11-2018
HGNC name helicase with zinc finger domain
HGNC id 16878
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
33 - 13851 - 1943 - 2003 12691822
33 - 13847 - 1942 - 2003 12691822
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   predominantly
Nervousbrain   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C3H1 type zinc finger
  • a DEXD consensus domain
  • ATP/GTP-binding site motif A (P-loop)
  • HOMOLOGY
    interspecies homolog to murine Helz
    Homologene
    FAMILY DEAD-helicase superfamily
    CATEGORY enzyme , DNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalyzes ATP-dependent unwinding of double-stranded DNA
  • playing a role in RNA metabolism in multiple tissues and organs with in the developing embryo
  • can inhibit growth of cancer cells
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    RNA metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • zinc Zn2+ binding
  • ATP/GTP binding
  • protein
  • SMYD2, similar to SMYD3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ
  • downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of RPS6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene loss of expression of HELZ may play a role in carcinogenesis
    Marker
    Therapy target
    ANIMAL & CELL MODELS