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FLASH GENE
Symbol KIAA0753 contributors: mct - updated : 13-04-2016
HGNC name KIAA0753
HGNC id 29110
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 4701 109.4 967 - 2021 34711653
19 - 4984 - 668 - 2021 34711653
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus (residues 1–299) was sufficient for localization to PSs (pericentriolar satellites) and centrosomes
  • large extent of disordered non-globular structures
  • C-terminus of the protein is one of the few regions that are predicted to be globular
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • KIAA0753 positively regulates centriole duplication and CEP63 centrosome localization
  • having microtubule-stabilizing activity
  • conserved centrosome and PS protein
  • protects from depolymerization and stabilizes Microtubules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a ternary complex with FOPNL and OFD1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WDR62 interacting with MOONRAKER (KIAA0753)
  • interacts with FOPNL
  • directly interacts with OFD1 in the absence of FOPNL, but the interaction between KIAA0753 and OFD1 is much stronger when FOPNL is present in the complex
  • CEP120 recruits KIAA0753 to centrioles, and loss of this interaction induces accumulation of granule neuron progenitors (GNPs) in the germinal zone and impairs neuronal differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OFD15 , SRTD21 , JBTS38
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS