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FLASH GENE
Symbol PTGFRN contributors: mct/pgu - updated : 17-03-2012
HGNC name prostaglandin F2 receptor negative regulator
HGNC id 9601
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 6160 - 879 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivemouthtongue  highly
 stomach   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 6 Ig-like C2-type (immunoglobulin-like) domains
  • a cytoplasmic tail, with a stretch of basic charged AAs that may act as binding sites for actin-linking ezrin-radixin-moesin (ERM) proteins
  • its cytoplasmic region contains potential calmodulin-dependent protein kinase phosphorylation sites and protein kinase C phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY immunoglobulin (Ig) superfamily protein
    CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text colocalized with ERM proteins at microspikes and microvilli of adherent cells and at the cellular uropod in polarized migrating leukocytes
    basic FUNCTION
  • prostaglandin F2 alpha receptor (FP), negative receptor
  • inhibiting the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor
  • through their direct interaction with ERM proteins, act as linkers to connect tetraspanin-associated microdomains to actin cytoskeleton regulating cell motility and polarity
  • self-associates independently from its association with tetraspanins, and tetraspanins can play a role on PDGFRN oligomerization status
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • IFITM5 forms a complex with FKBP11-CD81-PTGFRN
  • major component of the tetraspanin web, a network of molecular interactions in the plasma membrane, in which it specifically associates with tetraspanins CD9 and CD81
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct partner of tetraspanins CD9 (Tspan29) and CD81 (Tspan28)
  • CD81 associated with PTGFRN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS