basic FUNCTION
| acts in a negative feedback loop to attenuate canonical Wnt signaling, and may facilitate a switch to the non-canonical Wnt planar cell polarity (PCP) pathway that is involved in cell movements during morphogenesis |
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acts as a negative regulator of WNT/CTNNB1 pathway |
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DKK1, DKK2, DKK3, DKK4 are known to modulate Wnt/CTNNB1 signaling, which is activated during bone formation |
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functions as an inhibitor of osteoblastogenesis through WNT/CTNNB1 signaling |
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dynamic state of DKK4 itself and its interaction with LRP6 modulates WNT function during Meibomian gland (MG) development, with a novel limitation of DKK4 action by proteolytic cleavage |