motifs/domains
| N terminal hydrophilic nucleoplasmic domain |
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a hydrophobic domain with eight transmembrane segments, projecting into the nucleoplasm and binding to both B-type lamins and chromatin proteins |
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first transmembrane domain promotes the LBR-bearing membrane production and the nuclear envelope expansion in interphase |
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a lamin B binding |
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a tudor (TD) domain (AAs 1-62) that primarily recognizes histone H4 lysine 20 dimethylation and is essential for chromatin compaction, |
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a whole nucleoplasmic region (AAs 1-211) is required for transcriptional repression , and TD/RS interface may potentially operate as a "histone chaperone-like platform" |
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a sterol reductase like C-terminal domain having two functional domains: a highly homologous to sterol reductases and encoding sterol 14-reductase activity, playing a critical role in cholesterol biosynthesis, process essential to both myeloid cell growth and functional maturation |
SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,nuclear envelope,int
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text
| integral protein of the nuclear enveloppe inner membrane, binding the lamina to heterochromatin |
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integral membrane protein of the interphase nuclear envelope (NE) |
basic FUNCTION
| binding the lamina and the heterochromatin to the inner nuclear membrane |
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can interact with chromodomain proteins |
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bifunctional protein involved in nuclear organization and chromatin binding |
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playing an important role in targeting the nuclear envelope to chromatin in an importin beta-mediated process |
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integral nuclear envelope protein that interacts with chromatin and has homology to sterol reductases |
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possible mechanism involving PPP1CC and LBR for the regulation of nuclear membrane targeting to chromatin |
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recruited to chromatin through direct interaction with importin beta to contribute to the fusion of membrane vesicles and formation of the nuclear envelope |
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likely roles in post-mitotic nuclear reformation, interphase nuclear envelope growth and compartmentalization of nuclear architecture might have provided some evolutionary advantage to preservation of the LBR gene |
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polytopic protein of the nuclear envelope thought to connect the inner nuclear membrane with the underlying nuclear lamina and peripheral heterochromatin |
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plays a critical role in regulating myeloid differentiation |
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classical inner nuclear membrane protein that associates with heterochromatin |
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LMNA and LBR sequentially tether peripheral heterochromatin and inversely regulate differentiation |
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contributes to the functional integrity of the nucleus by tethering heterochromatin to the nuclear envelope |
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LBR possesses a modular structure and corresponding bifunctionality, acting in heterochromatin organization via its N-terminus and in cholesterol biosynthesis via its sterol-reductase C-terminal domain |