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FLASH GENE
Symbol TNR contributors: mct - updated : 05-02-2015
HGNC name tenascin R (restrictin, janusin)
HGNC id 11953
RNA
TRANSCRIPTS type messenger
text two alternative forms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 5190 - 1358 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
 brainforebraincerebral cortex   Homo sapiensFetal
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Nervouscentral    Homo sapiens
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte Homo sapiens
Nervousglia
Nervousneuron Homo sapiensAdult
Nervousoligodendrocyte Homo sapiensAdult
Visualhorizontal association cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine-rich segment,
  • 4,5 EGF-like repeats
  • 9 fibronectin type III-like repeats
  • a fibrinogen-like sequence
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine loop-tail,putatively
    Homologene
    FAMILY tenascin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text extracellular matrix
    basic FUNCTION
  • inhibitor of CD3-mediated T cell interaction
  • extracellular neural recognition molecule
  • TNC and TNR play antagonistic roles for differentiation and comparably inhibit morphologic maturation
  • is an extracellular matrix glycoprotein that is restricted to the central nervous system, where it acts as a multifunctional and versatile molecule
  • potential role for tenascin-R in corticogenesis
  • TNC and tenascin-R (TNR) play important roles in cell proliferation and migration, fate determination, axonal pathfinding, myelination, and synaptic plasticity
  • role of TNR in brain development and cognition
  • importance of TNR in the regulation of hippocampal neurogenesis, suggesting that TNR acts through distinct direct and indirect mechanisms during development and in the adult
  • TNC and tenascin-R (TNR), regulate differentiation and migration, in addition to neurite outgrowth and survival in numerous types of neurons and mesenchymal progenitor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text central nervous system development, axon guidance
    PATHWAY
    metabolism
    signaling
    a component
  • aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with fibronectin-dependent cell attachment and interaction
  • TNC and TNR interfered with the activation of the small GTPase RHOA
  • TNR is likely expressed in a subset of astrocytes and contributes to glutamate homeostasis by regulating astrocytic SLC1A3 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in a child with intellectual disability and transient choreoathetosis
    tumoral     --over  
    in pilocytic astrocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS