Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DHX34 contributors: mct - updated : 21-08-2015
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 34
HGNC id 16719
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 4385 128 1143 - 2011 21227923
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Nervousbrainhindbrainmedulla oblongata  
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelial    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
  • C terminal RNA helicase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • ATP-binding RNA helicase
  • having nucleic acid binding, helicase activities
  • acts as a scaffold required for successful NMD of aberrant mRNA transcripts
  • DHX34 and NBAS act in concert with core nonsense-mediated mRNA decay (NMD) factors to co-regulate a large number of endogenous RNA targets
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
  • ATP
  • protein
  • is recruited to the SURF complex via its preferential interaction with hypophosphorylated UPF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDRA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS