basic FUNCTION
| mediate inwardly-directed Na(+)/nucleoside cotransport, being broadly selective for both pyrimidine and purine nucleosides |
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transporting a broad range of physiological purine and pyrimidine nucleosides as well as anticancer and antiviral nucleoside drugs |
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mediates transport of a broad range of purine and pyrimidine nucleosides and nucleoside drugs |
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is also capable of H(+)-mediated nucleoside cotransport |
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uses the electrochemical gradient of Na(+) and H(+) to drive the transport of nucleosides and therapeutic nucleoside analogs into the cells |
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broad-selectivity, high-affinity protein implicated in the uptake of most nucleoside-derived anticancer and antiviral drugs |
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thought to concentrate nucleosides including cytidine, uridine, adenosine and guanosine in a cell by coupling translocation of two H+ or Na+ ions per nucleoside |
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is directly involved in the metabolism of two drugs (anthracycline and gemcitabine) |
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likely specific role in the sensory epithelium of the utricle and cochlea |