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FLASH GENE
Symbol LCMT1 contributors: mct - updated : 08-07-2015
HGNC name leucine carboxyl methyltransferase 1
HGNC id 17557
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 1374 38 334 - 2011 21292165
  • isoform a
    • 9 splicing 1209 32 279 - 2011 21292165
  • isoform b
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure
  • active-site pocket recognizes the C-terminus of PPP2CA, and, interestingly, the PPP2CA active site makes extensive contacts to LCMT1
    • HOMOLOGY
    interspecies homolog to murine Lcmt1 (88.9pc)
    homolog to rattus Lcmt1 (88.9pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text
  • underrepresented in the nucleus and mainly localizes to the cytoplasm, Golgi region and late endosomes
    • basic FUNCTION
  • involved in the methylation of the catalytic subunit of protein phosphatase 2A
  • is important for normal progression through mitosis and cell survival
  • potentially implicated in tight control of PPP2CA function, important for the cell cycle and cell survival
  • methylates the terminal carboxyl group of the leucine 309 residue of protein phosphatase 2A (PPP2CA), a key regulator of many cellular processes
  • the LCMT1-PPME1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division
    • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GSK3B can inhibit PPP2CA by increasing the inhibitory L309-demethylation involving upregulation of PPME1 and inhibition of LCMT1
  • LCMT1 and protein phosphatase methylesterase-1 (PPME1) are essential enzymes that regulate the methylation of the protein phosphatase 2A catalytic subunit (PP2AC)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Lcmt1 knockout in mice is embryonic lethal