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FLASH GENE
Symbol COMMD6 contributors: mct - updated : 14-04-2021
HGNC name COMM domain containing 6
HGNC id 24015
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1708 - 98 ubiquitous (except skeletal muscle), highly in liver and kidney 2019 31523056
4 - 1669 - 85 - 2019 31523056
4 - 1849 - 58 ubiquitous (except skeletal muscle), highly in liver and kidney 2019 31523056
3 - 1696 - 58 - 2019 31523056
5 - 1834 - 58 - 2019 31523056
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Hearing/Equilibriumearinnercochlea highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • COMM (copper metabolism gene MURR1) domain
  • HOMOLOGY
    Homologene
    FAMILY MURR1/COMMD1 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs
  • may modulate the ubiquitination and degradation of NF-&
  • 954;B subunits and regulate ribonucleoprotein and spliceosome complex biogenesis in tumours
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein inhibit TNF (tumour necrosis factor)-induced NF-kappaB activation in a non-synergistic manner
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in several non-small cell lung cancer (NSCLC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for tumour prevention
  • Therapy target
    ANIMAL & CELL MODELS