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FLASH GENE
Symbol UGT2B28 contributors: mct - updated : 09-12-2021
HGNC name UDP glycosyltransferase 2 family, polypeptide B28
HGNC id 13479
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 1857 54 529 - 2011 21679149
contains an endoplasmic reticulum (ER)-targeting signal, a membrane-anchoring region, and substrate- and cofactor-binding domains
4 splicing 1549 35 335 - 2011 21679149
  • UGT2B28 type 2
  • lacks the UDPGA-binding domain and the transmembrane region
  • - splicing 1300 42 412 - 2011 21679149
    retains the transmembrane region at its C-terminal end but lacks the substrate-binding domain
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivefemale systembreast   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • UDP-glycosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nuclear envelope,ext
    basic FUNCTION
  • glucuronosyltransferase activity
  • androgen-inactivating UGT2B28 enzyme influences hormone levels, clinical and pathologic factors, and the risk of cancer progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to variation of ages of hepatocellular carcinoma (HCC) occurrence
    Variant & Polymorphism other
  • UGT2B28 genomic variant was indicative of the age of HCC presentation, recurrence, distant metastasis and death
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS