Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BPIFA1 contributors: mct/npt - updated : 28-11-2017
HGNC name BPI fold containing family A member 1
HGNC id 15749
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 1035 - 256 - 2011 21787346
utilizes exon 9, and has a shorter 3' UTR
9 splicing 1090 - 256 - 2011 21787346
  • utilizes an alternate exon 9, referred to as exon 9a, and contains an additional 55 nt in the 3' UTR
  • 9 - 1074 - 256 - 2011 21787346
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Respiratorylung    
     respiratory tract     Homo sapiens
     respiratory tractlarynx    Homo sapiens
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningnasal epithelium   Homo sapiens
    Epithelialsensoryolfactory  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    cell lineage
    cell lines lung cancer cell lines (non small cell lung cancer)
    fluid/secretion bronchial mucus
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • leucine rich protein
  • a signal peptide
  • one N terminal-lys BPI domain
  • HOMOLOGY
    interspecies homolog to murine Plunc
    intraspecies paralog to BPI
    Homologene
    FAMILY
  • BPI/PLUNC family
  • PLUNC family proteins
  • CATEGORY immunity/defense , secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text present in the specific granules of the neutrophil (Bartlett 2008)
    basic FUNCTION
  • involved in the airway inflammatory response after exposure to irritant and in tumor progression
  • playing a role in host defenses in the mouth, nose, upper airways
  • may not only be an antimicrobial peptide that plays an important role in the maintenance of homeostasis in the upper respiratory tract, oculi, and alimentary tract, it may also be important in the development and lipid metabolism of the adipose tissue (Zhou 2006)
  • serves as a novel host defense protein against mycoplasma pneumoniae and an allergic setting markedly reduces PLUNC expression (Chu 2007)
  • participates in an aspect of the inflammatory response that contributes to host defense (Bartlett 2008)
  • not only has the role of antibacteria and antivirus, but also inhibits the potential oncogenicity of EBV in respiratory epithelium (Zhou 2008)
  • secreted onto mucosal surfaces as a soluble volume sensor whose concentration and dilution can regulate SCNN1A activity and mucosal volumes, including that of airway surface liquid (Garcia-Caballero 2009)
  • contributes to the surfactant properties of airway secretions, and that this activity may interfere with biofilm formation by an airway pathogen
  • antimicrobial and anti-inflammatory functions of BPIFA1 in Gram-negative bacteria-induced respiratory infection
  • exerts antimicrobial effects, regulates airway surface liquid and mucociliary clearance, and suppresses allergic airway inflammation
  • role of BPIFA1 and other PLUNC family members in host defense
  • is an abundant secretory product of epithelia present throughout the conducting airways
  • might be an important antimicrobial protein involved in innate immunity defense
  • abundantly secreted innate immune protein in the mammalian respiratory tract that exerts bacteriostatic and antibiofilm effects, binds to lipopolysaccharide (LPS), and acts as a fluid-spreading surfactant
  • critical role of BPIFA1 in the initial phase of infection by inhibiting the binding and entry of influenza A virus (IAV) into airway epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BPIFA1 degradation by ELANE may increase airway susceptibility to bacterial infection
  • interaction between BPIFA1 and lipids
  • cell & other
    REGULATION
    induced by retinoid acid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    loss of BPIFA1 is a crucial feature of host defense across air-breathing animal species
    Susceptibility to nasopharyngeal cancer
    Variant & Polymorphism
    Candidate gene for treatment and prevention of nasopharyngeal cancer
    Marker
  • may be a useful marker for tracing lung cancer cells, based on its epithelial origin property in pleural effusion (pMID: 26090599)
  • Therapy target
    SystemTypeDisorderPubmed
    allergyasthm 
    strategies that target ORAI1 or the BPIFA1 deficiency in asthma may lead to novel therapies to treat this disease
    ANIMAL & CELL MODELS
  • Splunc1 inhibits airway eosinophilic inflammation in allergic mice, in part by reducing eotaxin-2 production in alveolar macrophages