basic FUNCTION
| involved in the airway inflammatory response after exposure to irritant and in tumor progression |
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playing a role in host defenses in the mouth, nose, upper airways |
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may not only be an antimicrobial peptide that plays an important role in the maintenance of homeostasis in the upper respiratory tract, oculi, and alimentary tract, it may also be important in the development and lipid metabolism of the adipose tissue (Zhou 2006) |
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serves as a novel host defense protein against mycoplasma pneumoniae and an allergic setting markedly reduces PLUNC expression (Chu 2007) |
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participates in an aspect of the inflammatory response that contributes to host defense (Bartlett 2008) |
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not only has the role of antibacteria and antivirus, but also inhibits the potential oncogenicity of EBV in respiratory epithelium (Zhou 2008) |
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secreted onto mucosal surfaces as a soluble volume sensor whose concentration and dilution can regulate SCNN1A activity and mucosal volumes, including that of airway surface liquid (Garcia-Caballero 2009) |
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contributes to the surfactant properties of airway secretions, and that this activity may interfere with biofilm formation by an airway pathogen |
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antimicrobial and anti-inflammatory functions of BPIFA1 in Gram-negative bacteria-induced respiratory infection |
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exerts antimicrobial effects, regulates airway surface liquid and mucociliary clearance, and suppresses allergic airway inflammation |
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role of BPIFA1 and other PLUNC family members in host defense |
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is an abundant secretory product of epithelia present throughout the conducting airways |
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might be an important antimicrobial protein involved in innate immunity defense |
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abundantly secreted innate immune protein in the mammalian respiratory tract that exerts bacteriostatic and antibiofilm effects, binds to lipopolysaccharide (LPS), and acts as a fluid-spreading surfactant |
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critical role of BPIFA1 in the initial phase of infection by inhibiting the binding and entry of influenza A virus (IAV) into airway epithelial cells |