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FLASH GENE
Symbol SLC28A2 contributors: mct - updated : 15-04-2020
HGNC name solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
HGNC id 11002
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 4371 - 658 - 2001 11602688
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestine   moderately
 liver   moderately
Reproductivemale systemmale genital tractepididymis   Rattus norvegicus
Respiratorylung   lowly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepididymal cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminus tail is a domain implicated in transporter sorting (Cys(615) and Cys(649) are important residues for the proper trafficking of SLC28A2 to the plasma membrane)
  • HOMOLOGY
    interspecies homolog to murine Slc28a2
    intraspecies homolog to SLC28A1
    Homologene
    FAMILY SLC28A family of transporter
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues
  • may have a significant role in uptake of nucleoside drugs from the intestine and is a potential transporter target for the development of nucleoside and nucleoside-mimetic drugs
  • mediate the uptake of anticancer and some antiviral drugs and are also suitable candidates to facilitate nucleoside-derived drug uptake into hepatocytes for detoxification
  • SLC28A1, SLC28A2 are pyrimidine and purine nucleoside-selective, respectively
  • plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs
  • is a high-affinity adenosine transporter that may play physiological roles beyond nucleoside salvage
  • is likely to modulate extracellular adenosine and cell energy balance in neuronal tissue
  • is a purine-preferring concentrative nucleoside transporter implicated in the regulation of extracellular adenosine levels and purinergic signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text purine nucleoside transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDIA3 appeared to be a negative effector of SLC28A2 function, whereas ALDOB flux modulated SLC28A2 activity via a mechanism involving acquisition of higher affinity for its substrates
  • cell & other
    REGULATION
    inhibited by by formycin B
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increases during gestation
    Susceptibility to gout
    Variant & Polymorphism other
  • associations of the SLC28A2 gene variant Rs16941238 with the Serum uric acid (SUA)level, hyperuricemia (HUA) and gout
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS