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FLASH GENE
Symbol SEPTIN7 contributors: mct - updated : 30-08-2019
HGNC name septin 7
HGNC id 1717
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4380 - 437 - 2011 22064074
14 splicing 4377 - 436 - 2011 22064074
12 - 4272 - 401 - 2011 22064074
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Hearing/Equilibriumearinnercochlea highly Homo sapiensFetal
Nervousbrainlimbic systemhippocampus highly Homo sapiensFetal
 brain   highly Homo sapiens
Reproductivemale systemtestis  highly
Respiratoryrespiratory tractlarynx  predominantly
Skin/Tegumentskin   highly
Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervousperipherous  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Urinarypodocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text lung, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved GTP-binding domain (SEPT7G) forming filaments within the crystal
  • C-terminal coiled-coil region interacting with CENPE, C-terminal domain, which is often predicted to adopt a coiled-coil conformation, at least in part
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae CDC10
    Homologene
    FAMILY septin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in cytokinesis
  • forms a link between kinetochore distribution of CENPE and the mitotic spindle checkpoint
  • important role for SEPT7 in regulating dendritic branching and dendritic-spine morphology
  • may be involved in the regulation of subcellular-compartment formation during spermiogenesis
  • may participate in the regulation of glucose transport in podocytes
  • may influence recruitment of alpha-tubulin to spindles
  • forms a very tight G interface dimer in the GDP-bound state
  • SEPTIN6 and SEPTIN7 complexes bound to F-actin regulate protein sorting during multivesicular body (MVB) biogenesis
  • SEPTIN6 and SEPTIN7 function in the spatial, temporal organization of AP3B1- and ESCRT-coated membrane domains
  • SEPT2 and SEPT7 are involved in breast carcinogenesis
  • expression of non-SUMOylatable septin variants from the SEPT6 and SEPT7 groups leads to aberrant septin bundle formation and defects in cytokinesis after furrow ingression
  • SEPTIN2, SEPTIN7, and SEPTIN9 are required for efficient bacterial invasion
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9 and the three members of this complex colocalize along the length of the axoneme
  • SEPT6-C and SEPT7-C are able to form both homo- and heterodimers with a high alpha-helical content in solution
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • stabilizes the kinetochore association of CENPE by directly interacting with its C-terminal domain (key role for the SEPT7-CENPE interaction in the distribution of CENPE to the kinetochore and achieving chromosome alignment)
  • SEPTIN3 directly binds to SEPTIN5 and SEPTIN7 and forms a heteromeric complex at nerve terminals adjacent to where a synaptic vesicle marker, synaptophysin, is expressed in mature neurons
  • SEPT7 associates with CD2AP and NPHS1, both essential for glomerular ultrafiltration
  • HDAC6 requires SEPT7 not for its enzymatic activity, but to associate with acetylated alpha-tubulin
  • TAOK2 directly phosphorylates the cytoskeletal GTPase SEPTIN7, at an evolutionary conserved residue, and this phosphorylation induces translocation of SEPTIN7 to the spine, where it associates with and stabilizes the scaffolding protein DLG4, promoting dendritic spine maturation
  • cell & other
    REGULATION
    Other endogenous SEPT7 is constitutively SUMOylated during the cell cycle
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    may serve as valuable therapeutic targets for breast cancer
    ANIMAL & CELL MODELS