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FLASH GENE
Symbol ZNF253 contributors: - updated : 11-03-2006
HGNC name zinc finger protein 253
HGNC id 13497
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunethymus   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
cell lineage monocytic and immature erythroid cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text skeletal muscle, heart, and pancreas, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KRAB (Krüppel associated box) domain
  • eleven C2H2 zinc finger domains at the C-terminus
  • conjugated MetalloP
    HOMOLOGY
    intraspecies homolog to ZNF92
    Homologene
    FAMILY Kruppel family of C2H2-type zinc finger proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • mediating transcriptional repression
  • may be involved in the heart development, and it probably works as a negative regulator in MAPK signaling pathway
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS