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FLASH GENE
Symbol ACBD3 contributors: - updated : 01-09-2007
HGNC name acyl-Coenzyme A binding domain containing 3
HGNC id 15453
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrine   highly
 thyroid   highly
Reproductivefemale systemovary  highly
 male systemtestis  highly
 male systemseminal vesicles  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousglia
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in all tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal PTB domain essential for NUMB activity
  • a proline-rich N terminal domain and an acyl-CoA-binding motif
  • a C terminal Golgi localization signal (NLS)
  • the GRID domain
  • a GOLGB1 binding domain
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY Golgin subfamily
    CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • colocalized with GOLGB1 to the juxtanuclear region
  • associates with the Golgi Apparatus (localizing to the cytoplasmic face of the Golgi membranes)
  • becomes cytosolic only during mitosis
  • basic FUNCTION
  • involved in the maintenance of Golgi structure and function through its interaction with giantin (GOLGB1)
  • affecting protein transport between the endoplasmic reticulum and Golgi
  • functioning as an A-kinase anchoring protein (AKAP) critical in the cAMP-dependent steroid formation
  • may participate in PRKAR1A-mediated tumorigenesis and hypercortisolism
  • having roles in the Golgi, is involved in posttranslational modification and trafficking of proteins but not required for the process of Golgi fragmentation, which is essential for cell-cycle progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GOLGB1/giantin
  • interacting with NUMB through an essential NUMB domain (it is an essential NUMB partner in cell-fate specification)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS