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FLASH GENE
Symbol ADAMDEC1 contributors: mct - updated : 27-12-2022
HGNC name ADAM-like, decysin 1
HGNC id 16299
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2348 52.7 470 - 2020 31627897
15 - 2438 - 391 - 2020 31627897
13 - 2229 - 391 - 2020 31627897
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon highly
Lymphoid/Immunelymph node   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialabsorptive excretorydigestive epithelium  
Epithelialbarrier/lininguroepithelium  
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide for directing secretion and a relatively large (173-residue) prodomain, predicted to be cleaved off during maturation
  • partial lack of a disintegrin domain and total lack of a cysteine-rich domain
  • a furin cleavage site and zinc-binding sites
  • a metzincin metalloprotease domain harboring a putative zinc-binding active site consensus sequence
  • a transmembrane domain, and a variable cytoplasmic tail
  • conjugated MetalloP
    isoforms Precursor mature protein only comprises a metzincin metalloprotease domain and a short disintegrin-like domain
    HOMOLOGY
    intraspecies homolog to ADAM15
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • reprolysin (M12B) family of zinc metalloproteases
  • metzincin superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • playing a role in dentritic cell function and their interactions with germinal center T cells
  • having a similar function as ADAM7 and ADAM28
  • secreted as a mature, glycosylated, and proteolytically active metalloprotease, capable of cleaving macromolecular substrates
  • sheddase, which initiates an FGF autocrine loop to promote stemness in cancer stem cells
  • is an orphan ADAM-like metalloprotease which is believed to be closely related to inflammation
  • ADAMDEC1 plays a pro-inflammatory role in rosacea via modulating the M1 polarization of macrophages
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    activated by upregulated during dentritic cells maturation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    with MMP12, in bronchoalveolar lavage samples from patients with sarcoidosis, correlating with disease severity
    constitutional     --over  
    in the skin lesions of rosacea patients
    tumoral     --over  
    significantly elevated in gliomas
    constitutional     --low  
    might be involved in the development of preeclampsia
    constitutional     --over  
    of ADAMDEC1 RNA in monocytes from patients with systemic lupus erythematosus
    Susceptibility to venous thromboembolism with high factor VIII levels
    Variant & Polymorphism SNP TGTGG haplotype may indicate an underlying mechanism for high FVIII levels
    Candidate gene
    Marker has potential as a glioma clinical marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    has potential as immunotherapy target
    ANIMAL & CELL MODELS