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FLASH GENE
Symbol WNT16 contributors: mct/npt - updated : 28-03-2015
HGNC name wingless-type MMTV integration site family, member 16
HGNC id 16267
RNA
TRANSCRIPTS type messenger
text two transcript variants diverging at the 5' termini and produced by separate promoters
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2894 - 355 - 2009 19951988
  • WNT16a (short form)
  • difference in the 5' terminus including 5' UTR and the coding region for the N-terminus (1st exon)
  • 4 initiation site 3132 40.7 365 expressed only in pancreas 2009 19951988
  • WNT16b
  • an hydrophobic signal peptide and many conserved cysteine residues
  • upregulated in basal cell carcinomas compared with normal skin
  • activated the Jun-N-terminal kinase cascade (may be involved in the activation of a non-canonical WNT signalling pathway)
  • activates keratinocyte proliferation possibly via a beta-catenin-independent non-canonical WNT transduction pathway
  • is a new marker of senescence that regulates TP53 activity and the PI3K/AKT pathway and is necessary for the onset of replicative senescence
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Nervousbrain    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans W08d2.1
    Homologene
    FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text associated with the extracellular matrix
    basic FUNCTION
  • ligand for members of the frizzled family of seven transemembrane receptors
  • plays an important role in leukemogenesis, raising its therapeutic interest
  • is an important determinant of cortical bone thickness (CBT) and bone mineral density (BMD), bone strength, and risk of fracture
  • is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt/CTNNB1 pathway
  • regulates the somitic expression of two Notch ligands, deltaC (dlc) and deltaD (dld), whose combined function is required for HSC fate
  • antagonistic role for WNT16 in the chondrogenic transformation of vascular smooth muscle cells (VSMCs)
  • attenuates TGFB-Induced chondrogenic transformation in vascular smooth muscle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
    Susceptibility
  • to osteoporotic fractures
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS