basic FUNCTION
| ligand for members of the frizzled family of seven transemembrane receptors |
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plays an important role in leukemogenesis, raising its therapeutic interest |
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is an important determinant of cortical bone thickness (CBT) and bone mineral density (BMD), bone strength, and risk of fracture |
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is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt/CTNNB1 pathway |
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regulates the somitic expression of two Notch ligands, deltaC (dlc) and deltaD (dld), whose combined function is required for HSC fate |
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antagonistic role for WNT16 in the chondrogenic transformation of vascular smooth muscle cells (VSMCs) |
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attenuates TGFB-Induced chondrogenic transformation in vascular smooth muscle |