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Symbol TRIM4 contributors: KTN/npt - updated : 09-02-2009
HGNC name tripartite motif-containing 4
HGNC id 16275
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 3401 57.3 500 - Reymond (2001)
6 splicing 3323 54 474 - Reymond (2001)
  • lacking 78 nt compared to the alpha variant
  • reading frame maintained
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger
  • two B-box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • RFP-like domain
  • a C terminal B30-2/SPRY domain
  • HOMOLOGY
    Homologene
    FAMILY
  • B box family, RBCC (TRIM family)
  • C-IV TRIM family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS