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FLASH GENE
Symbol TREX2 contributors: mct/npt - updated : 08-09-2009
HGNC name three prime repair exonuclease 2
HGNC id 12270
RNA
TRANSCRIPTS type messenger
text alternative promoter, varied sites for 3' cleavage
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2260 - 236 - Esposito, Hahn, Chen (2007)
2 splicing 1255 - 236 - Chen (2007)
- splicing 2116 - 236 - Chen (2007)
- splicing 1982 - 279 - Chen (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
cell cycle     cell cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three conserved exonuclease motifs with an HXAXXD sequence in the third motif
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Trex2
    Homologene
    FAMILY
  • exonuclease superfamily
  • TREX family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • catalyzing excision of nucleoside monophosphates from 3' termini of DNA (exonuclease)
  • may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity
  • may play a role in DNA repair
  • nonprocessive enzyme that removes nucleotides at DNA 3' termini
  • plays an important function during DNA metabolism and cellular proliferation
  • undergoes a conformational change in the active site upon DNA binding including ordering of active site residues and a shift of an active site helix (de Silva 2009)
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA TREX2–DNA complex has revealed new information about the interaction of this enzyme with substrate (De Silva 2009)
    RNA
    small molecule
    protein
  • with UCH37
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS