Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SEPN1 contributors: mct/npt - updated : 18-02-2012
HGNC name selenoprotein N, 1
HGNC id 15999
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 4255 62.1 556 - Maghadaszadeh, Okamoto (2006)
  • exon 3 spliced
  • endoplasmic reticulum membrane
  • N-glycosylated
  • 13 splicing 4357 - 590 - Maghadaszadeh, Okamoto (2006)
  • full-length transcript
  • skeletal muscle, brain, lung and placenta
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Endocrinepancreas   highly
    Nervousbrain    
    Reproductivefemale systemovary  highly
     male systemprostate  highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing retention targeting signal
  • two potential ER targeting signals
  • a di-arginine motif
  • an EF-hand domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Sepn1
    Homologene
    FAMILY
  • selenocysteine-containing protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a role in early development and in cell proliferation or regeneration
  • the ryanodine receptor (RyR) intracellular calcium release channel, are both required for normal muscle development and differentiation and for some calcium mobilization events in the embryo
  • plays a key role in redox homeostasis and human cell protection against oxidative stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with RyRs and functions as a modifier of the RyR channel (modulator of RyR activity)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RSMD1 , CFTD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS