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FLASH GENE
Symbol GCA contributors: npt/mct - updated : 07-01-2009
HGNC name grancalcin, EF-hand calcium binding protein
HGNC id 15990
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1642 24 217 - Hillier (2005)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Lymphoid/Immunelymph node   highly
Nervousnerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticneutrophil
Lymphoid/Immunelymphocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines promyelocytic cell lines HL60S
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five EF-hand calcium-binding motifs
  • one potential phosphorylation
  • two potential glycosylation sites
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • sorcin/grancalcin/calpain light chain subfamily
  • penta-EF hand (PEF) family of calcium binding proteins
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a role in granule-membrane fusion and degranulation
  • may be playing a role in regulation of adherence and migration of neutrophils
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer of 55kDa
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • with L-plastin (in a negative calcium dependant manner), a protein known to have actin bundling activity
  • cell & other associate with membranes in Ca(2+)-dependent manner
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS