basic FUNCTION
| involved in actin filament organization by generating filopodial structures (Carbone 2008) |
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has the conserved Rho GTPase domain structures and cycles between a GDP-bound inactive form and a GTP-bound active form |
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RHOF provides an alternative route to filopodia generation in other cell types and is expressed in platelets |
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functional overlap between RHOF and other small GTPases may be responsible for the non-essential role of RHOF in platelets |
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RHOF promotes likely marginal zone(MZ) B cell development in the spleen |
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in combination with RAC1 and CDC42, causing actin rearrangments that suggesting its involvement in regulation of the cytoskeleton |
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RHOF shares a conserved mechanism of GTP hydrolysis with other RAS superfamily GTPases |
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regulates the formation of filopodia and stress fibers in cells |
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is indispensable for both extracellular and intracellular pattern-recognition receptor-mediated innate immune responses |