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FLASH GENE
Symbol NFX1 contributors: mct/npt - updated : 10-06-2009
HGNC name nuclear transcription factor, X-box binding 1
HGNC id 7803
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3200 - 833 - Katzenellenbogen (2007)
24 - 4629 - 1120 - Katzenellenbogen (2007)
16 - 3548 - 833 - Katzenellenbogen (2007)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunethymus   highly
Respiratoryrespiratory tracttrachea  highly
 respiratory tractlarynx  highly
cell lineage
cell lines all cell lines tested
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • R3H domain
  • NF-X1 type zinc finger motifs
  • zinc finger domain (Ring type)
  • central cystein rich DNA binding domain subdivised into seven repeated motifs
  • HOMOLOGY
    interspecies homolog to murine Nfx1
    homolog to C.elegans c16a3.7
    Homologene
    FAMILY
  • NFX1 family
  • CATEGORY enzyme , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in regulation of the duraton of an inflammatory response
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS inflammation
    text pol2 transcription
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • specific binding partner for ELAVL4
  • NFX1-91 interacts with the corepressor complex SIN3A/histone deacetylase (HDAC) at the TERT promoter, and repress TERT transcription in keratinocytes (Xu 2008)
  • cell & other
    REGULATION
    induced by interferon gamma (IFNG)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS