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FLASH GENE
Symbol MYO1B contributors: mct - updated : 21-05-2012
HGNC name myosin IB
HGNC id 7596
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
31 - 5113 - 1136 - 2005 16254000
six non-identical IQ motifs
29 - 4939 - 1078 - 2005 16254000
five non-identical IQ motifs
31 - 4951 - 1136 - 2005 16254000
four non-identical IQ motifs
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 liver   moderately
 mouth   predominantly
 pharynx   moderately
Hearing/Equilibriumearinnercochlea highly
Nervousnerve   moderately
Reproductivefemale systembreastmammary gland moderately
Urinarybladder   moderately
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a myosin head-like domain
  • six IQ domains, binding calmodulin with a range of affinities
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus Myo1b (95.9 pc)
    homolog to murine Myo1b (97.9 pc)
    Homologene
    FAMILY myosin superfamily
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytoskeleton
    text
  • concentrates on endosomal and ruffling membranes
  • associates with the plasma membrane and certain subcellular organelles such as endosomes and lysosomes
  • basic FUNCTION
  • participating in process critical to neuronal development
  • functioning such as cell migration, neurite outgrowth and vesicular transport
  • controls the traffic of protein cargo in multivesicular endosomes most probably through its ability to modulate with actin the morphology of these sorting endosomes
  • play roles in membrane trafficking and dynamics
  • may play a role in the local midgut response pathway of the Imd innate immune response to Gram-negative bacterial infection
  • is substantially more tension-sensitive than other myosins with similar length lever arms, indicating that different myosins have different tension-sensitive transitions
  • regulates the actin-dependent post-Golgi traffic of cargo, generates force that controls the assembly of F-actin foci and, together with the actin cytoskeleton, promotes the formation of tubules at the trans-Golgi network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • myosin complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • binding to acting
  • binding to calmodulin
  • binding of MYO1B to phosphoinositides plays an important role in vivo by regulating localization to actin-enriched membrane projections
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS