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FLASH GENE
Symbol MRPS2 contributors: mct - updated : 22-05-2018
HGNC name mitochondrial ribosomal protein S2
HGNC id 14495
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1516 33 296 - 2001 11279123
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to E.Coli 30S subunit proteins
homolog to C.elegans Mrps2
homolog to Drosphila Mrps2
homolog to yeast S.cerevisiae Mrps2
ortholog to bacterial bS2
Homologene
FAMILY
  • ribosomal protein S2P family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    text mitochondrial ribosome
    basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • in contrast to MRPS11, MRPS2 is able to assemble into a rapidly sedimenting particle to a significant extent in the absence of either MRPS16 or MRPS22
  • plays likely an important but currently unclear role in mitoribosomal biogenesis or function
  • structural role for MRPS2 in the connection of different domains of the mitochondrial ribosome
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small subunit (28S) of the mitochondrial ribosome, including two RNA molecules and 78 MRPs among which 31 proteins for the small subunit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COXPD36
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS