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FLASH GENE
Symbol KCNK16 contributors: mct/npt - updated : 03-03-2009
HGNC name potassium channel, subfamily K, member 16
HGNC id 14464
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1226 34.15 309 - Han (2003)
four transmembrane segments (Han 2003)
5 - 1412 - 322 - Mungall (2003)
  • lacked the fourth transmembrane domain because of deletion of exon 5 (Han 2003)
  • - - 947 - 294 - Mungall (2003)
  • four transmembrane segments (Han 2003)
  • sensitive to changes in external pH (Han 2003)
  • 5 - 1110 - 262 - Mungall (2003)
  • lacked the fourth transmembrane domain because of deletion of exon 5 (Han 2003)
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two pore-forming P domains
  • four transmembrane segments
  • HOMOLOGY
    Homologene
    FAMILY
  • tandem-pore K+ channel family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • two-pore region (2P) KCNK K+ channel gated open by extracellular alkalinization (Niemeyer 2007)
  • may serve as background K+ currents in certain cells of the pancreas (Han 2003)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by alkaline PH
    strongly and specifically activated by nitric oxide superoxide anion and singlet oxygen (Duprat 2005)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS