basic FUNCTION
| involved in transcription regulation |
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implicated in many cellular activities, including DNA replication, transcriptional control, heterochromatin assembly, centromere and telomere function |
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with ORC2 and CBX5, may be recruited to the chromatin as a single complex and require each other for their stable association to heterochromatin |
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involvement of ORC1, ORC2, ORC3 in the maintenance of constitutive heterochromatin |
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together with CBX proteins may be involved in organizing higher-order chromatin structure and centromere function |
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conserved role of ORC5 in modulating DNA structure to facilitate origin selection and helicase loading in eukaryotes |