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FLASH GENE
Symbol SYTL2 contributors: mct - updated : 15-11-2018
HGNC name synaptotagmin-like 2
HGNC id 15585
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 splicing 4280 102.4 910 - 2014 24284068
encoding the longer isoform with at least 19 exons and sharing the last 8 exons with variant b
9 splicing 2401 42.6 376 - 2014 24284068
using the last 8 exons of transcript variant a and containing an internal unique exon
13 - 4807 141.6 1272 - 2014 24284068
12 - 4759 139.7 1256 - 2014 24284068
12 - 2432 42.6 376 - 2014 24284068
9 - 2622 41.4 365 - 2014 24284068
10 - 2672 38.4 336 - 2014 24284068
17 - 4142 104.8 934 - 2014 24284068
  • isoform Slp2a-hem
  • associates with RAB27a in cytotoxic T cells and participates to cytotoxic granule secretion (PMID: 18812475)
  • 18 - 4060 105 935 - 2014 24284068
    19 - 3951 - 902 - 2014 24284068
    11 - 2785 - 255 - 2014 24284068
    11 - 2356 - 336 - 2014 24284068
    19 - 4287 - 911 - 2014 24284068
    18 - 3794 - 862 - 2014 24284068
    10 - 2469 - 376 - 2014 24284068
    11 - 2323 - 376 - 2014 24284068
    11 - 2517 - 376 - 2014 24284068
    8 - 2254 - 325 - 2014 24284068
    7 - 2083 - 268 - 2014 24284068
    10 - 2228 - 365 - 2014 24284068
    8 - 2203 - 308 - 2014 24284068
    11 - 2319 - 429 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal Slp homology domain
  • made of two conserved region SHD/SH2 linked together
  • two protein KC conserved region to (CALCB) C2 at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • synaptotagmin, C2 domain containing protein family
  • CATEGORY regulatory , secretory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text synaptic vesicles
    basic FUNCTION
  • both SYTL1 and SYTL2 may form part of a docking complex, capturing secretory lysosomes at the immunological synapse
  • is required for cytotoxic granule docking at the immunologic synapse
  • functions as a low affinity, fast exocytic Ca(2+) sensor in neurons, where it is activated by Ca(2+) influx through voltage-gated channels
  • can serve as an exocytic sensor for diverse Ca(2+) signaling systems, and its levels are limiting for stimulated secretory function in airway goblet cells
  • is required for stress-induced mitochondrial hyperfusion
  • is required for targeting of the signaling molecule podocalyxin to the apical membrane in a RAB27A-dependent manner
  • controls renal cell size through regulation of Rap-ezrin signaling independently of RAB27A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular traffick
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding RAB27A/B (GTP bound form)
  • CALM1 suppresses SYTL2 transcription in cortical neurons
  • SYTL2 is a RAB27A effector protein that regulates transport of RAB27A-bearing vesicles and organelles through its N-terminal RAB27A-binding domain and a phospholipid-binding C2A domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    promoted metastatic potential, including increased migration and invasiveness in the ovarian carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS