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FLASH GENE

Symbol

HRH4

contributors: - updated : 19-07-2007

HGNC name	histamine receptor H4
HGNC id	17383

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   liver       highly Lymphoid/Immune spleen       highly   thymus       highly Nervous brain       lowly Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP , LipoP

HOMOLOGY

interspecies	homolog to chimpanzee HRH4 (98.7 pc)
	homolog to rattus Hrh4 (69.9 pc)
	homolog to murine Hrh4 (68.9 pc)

intraspecies

homolog to HRH3

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	could mediate the histamine signals in peripheral tissues
	acting as an histamine receptor
	acting as a rhodopsin-like receptor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and this regulation may depend on the presence of IL-10 or IL-13

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS