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FLASH GENE
Symbol EFNA3 contributors: mct - updated : 04-02-2012
HGNC name ephrin-A3
HGNC id 3223
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1782 - 238 - 2009 19592509
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
 intestinesmall intestine   
Endocrineadrenal gland   highly
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text
  • expressed in the developing striatum, an area that is strictly avoided by migrating cortical interneurons
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text GPI anchored, membrane protein
    basic FUNCTION
  • membrane bound (glycosyl-phosphatidylinositol linkage) ligand for Eph-related kinase receptor tyrosine
  • EFNA2, EFNA3, EFNA5, and neural activity act together to control patterning of eye-specific retinogeniculate layers
  • physiological role for heparan sulfate proteoglycans in the regulation of EFNA3-dependent biological processes
  • involved in short-range contact-mediated axonal guidance
  • playing a specific role in postnatal neurogenesis
  • potentially acting as a repulsive cue that restricts cortical interneurons from entering inappropriate regions and thus contributing to define the migratory route of cortical interneurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • EPHA4/EFNAA3 signaling is potentially a critical mechanism for astrocytes to regulate synaptic function and plasticity
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHA7
  • binds to heparan sulfate, and the presence of cell surface heparan sulfate is required for the full biological activity of EFNA3
  • interaction between neuronal EPHA4 and glial EFNA3 bidirectionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function
  • interactions between the ephrin-A3 ligand and the EPHA4 receptor regulate the structure of excitatory synaptic connections through neuroglial cross-talk
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS