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FLASH GENE
Symbol CDC42EP4 contributors: npt/mct - updated : 287/08/200
HGNC name CDC42 effector protein (Rho GTPase binding) 4
HGNC id 17147
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3121 37 356 - Olsen (2006)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouth   highly
Endocrinepancreas   highly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
Respiratorylung   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved CRIB, BH1 and three BH3 domain
  • BH2 domain
  • HOMOLOGY
    interspecies ortholog to murine Borg4-pending
    homolog to Drosophila CG.7526
    homolog to C.elegans Y64G10A7
    Homologene
    FAMILY
  • CDC42 binding protein family
  • BORG/CEP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text membrane-associated
    basic FUNCTION
  • regulating the organisation of the actin cytoskeleton
  • may be playing a role in inducing actin filament assembly and cell shape control
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell shape control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • binding to CDC42
  • binding to TC10
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS