basic FUNCTION
| catalyzing the covalent attachment of ubiquitin to other proteins |
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required for the destruction of mitotic cyclins |
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involved in negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle |
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with UBE2S, likely constitute the physiological E2 module for the ANAPC during mitosis, in which UBE2C initiates and UBE2S elongates K11-linked ubiquitin chains (Williuamson 2009) |
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with UBE2C, constitute a physiological E2-module for ANAPC, the activity of which is required for spindle assembly and cell division (Williuamson 2009) |