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FLASH GENE
Symbol XAB2 contributors: KTN/npt/pgu - updated : 09-07-2008
HGNC name XPA binding protein 2
HGNC id 14089
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2682 99 855 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   moderately
Endocrineadrenal gland    
 thyroid   predominantly
Lymphoid/Immunelymph node   moderately
 spleen    
Nervousbrain    
Reproductivefemale systemplacenta  moderately
 female systemovary  moderately
 male systemprostate  moderately
Respiratorylung    
Skin/Tegumentskin   moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion highly in blood and lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • foureen HAT repeats
  • ten tetratricopeptide repeats (TPR)
  • HOMOLOGY
    interspecies homolog to dog XAB2 (98.8 pc)
    homolog to rattus Xab2 (99 pc)
    homolog to murine Xab2 (98.8 pc)
    Homologene
    FAMILY
  • crooked-neck family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text spliceosome
    basic FUNCTION
  • involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, repair, nucleotide excision repair
    nucleotide, transcription, regulation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS development
    text
  • mRNA processing
  • blastocyst development
  • PATHWAY
    metabolism
    signaling
    a component
  • associated with RNA polymerase II
  • INTERACTION
    DNA
    RNA
    small molecule
    protein binding to XPA, CSA, CSB, POLR2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS