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FLASH GENE
Symbol KAT7 contributors: mct/pgu - updated : 15-01-2014
HGNC name K(lysine) acetyltransferase 7
HGNC id 17016
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3664 70.6 611 - 2012 22144582
14 - 3574 - 581 - 2012 22144582
13 - 3334 - 501 - 2012 22144582
13 - 3247 - 472 - 2012 22144582
- - 3157 - 442 - 2012 22144582
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly Homo sapiensFetal
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiensAdult
ReproductiveSertoli cell Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal transcriptional repression domain
  • zinc finger domain (C2HC zinc finger)
  • histone acetyltransferase domain
  • a PHD domain
  • HOMOLOGY
    Homologene
    FAMILY
  • MOZ/SAS family
  • MYST family
  • CATEGORY enzyme , regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulation of AR-dependent genosin in normal and prostate cancer cells
  • positive regulatory factor for pre-RC (prereplicative complex) assembly
  • may be involved in the regulation of eukaryotic transcription
  • can acetylate nucleosomal histone H4
  • transcriptional coactivator
  • associating with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor CDT1
  • integrates internal and external stimuli to coordinate transcriptional responses with initiation of DNA replication
  • H4-specific histone acetylase, is a coactivator of the DNA replication licensing factor CDT1
  • primary role in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development
  • acetylates lysine residues of histones and is involved in DNA replication and gene transcription
  • promotes destabilization of estrogen receptor (ESR1) in breast cancers through lysine 48-linked ubiquitination
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PHF17-KAT7 complex implicated in acute kidney injury, suggesting distinct roles for PHF17 isoforms during epithelial cell recovery
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ORC1
  • AR
  • interacting with CDC2L2 (a novel regulator of MYST2)
  • directly interacting with CDT1
  • coactivator both for AP-1 transcription factors responding to stress-activated JNK kinases and also for the CDT1 licensing factor that ensures that DNA is replicated exactly once per cell cycle
  • importance of ING association with KAT7 in controlling cell proliferation
  • PHF17 bind KAT7 and promote acetylation of histones in chromatin context
  • BRPF1 activating 3 lysine acetyltransferases (KAT6A, KAT6B, and KAT7), suggesting that this protein has the potential to stimulate crosstalk between different chromatin modifications
  • cell & other
    REGULATION
    inhibited by GMNN, that inhibits KAT7 acetylase activity in the context of a CDT1-KAT7 complex, and it associates with origins and inhibits H4 acetylation and licensing
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    highly expressed in carcinomas of the testis, ovary, breast, stomach/esophagus, bladder
    constitutional     --low  
    expression was reduced in testes of patients with Androgen insensitivity syndrome, (AIS) compared to normal testes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    modulation of ER stability by KAT7 in breast cancers may provide a novel therapeutic possibility
    ANIMAL & CELL MODELS