Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC30A3 contributors: mct/pgu - updated : 02-09-2011
HGNC name solute carrier family 30 (zinc transporter), member 3
HGNC id 11014
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2108 41.9 388 - 2008 17971500
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine Znt3
    Homologene
    FAMILY
  • cation diffusion facilitator (CDF) family of metal ion transporters
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • membrane of synaptic vesicles
  • localized in clear synaptic vesicles of cortical glutamatergic terminals
  • basic FUNCTION
  • transport of zinc out of the cytoplasm into synaptic vesicles
  • evidently controls not only the "stainability" but also the actual mass of zinc in mossy-fiber synaptic vesicles (thus confirming its metal-transporting role in the brain)
  • responds to glucose- and zinc variations in beta-cells and is critical for insulin production during beta-cell stress
  • important for zinc homeostasis modulating presynaptic MAPK signaling and is required for hippocampus-dependent memory
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with AP3B1 and it is preferentially targeted to a distinct synaptic vesicle subpopulation
  • interacting with AP3B1, through its cytosolic tail
  • cell & other
    REGULATION
    activated by SERPINF1 in RPE
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the amyloid plaques of Alzheimer disease brain (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    ZnT3KO mice showed normal memory for fear conditioning and passive avoidance, even under gradual training regimes designed to unmask potential ceiling effects in the expression of memory