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FLASH GENE
Symbol PHOX2A contributors: - updated : 13-09-2007
HGNC name paired-like (aristaless) homeobox 2a
HGNC id 691
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Endocrineadrenal glandmedulla   
Nervousbrain    
 nervecranial nerveoculomotor nerve  
 nervecranial nervetrochlear nerve  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervousautonomous   
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text during neuronal differentiation
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an helix-turn-helix and paired DNA binding domains
HOMOLOGY
interspecies homolog to Drosophila aristaless
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • functioning as a transcriptional activator of the promoter of the dopamine beta hydroxylase (DBH)
  • involved in the midbrain motor nuclei development (III and IV)
  • participates in specifying the autonomic nervous system, and involved in the transcriptional control of the noradrenergic neurotransmitter phenotype as it regulates the gene expression of tyrosine hydroxylase and dopamine hydroxylase
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediating protein kinase stimulated dopamine beta-hydroxylase gene transcription
  • capable of regulating the transcription of the 3 nicotinic acetylcholine receptor gene (CHRNA3), which encodes the ligand-binding subunit of the ganglionic type nicotinic receptor
  • interacting with TLX2 (involved in the cascade leading to TLX2 transactivation and presumably in the intestinal neuronal differentiation)
  • cell & other
    REGULATION
    Other regulated by PMX2B
    ASSOCIATED DISORDERS
    corresponding disease(s) FEOM2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS